Jinbao Liu Selected Research

Auranofin (Ridaura)

8/2021	Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30.
3/2019	Auranofin lethality to prostate cancer includes inhibition of proteasomal deubiquitinases and disrupted androgen receptor signaling.
1/2016	Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo.
1/2015	Inhibition of 19S proteasome-associated deubiquitinases by metal-containing compounds.
11/2014	Novel use of old drug: Anti-rheumatic agent auranofin overcomes imatinib-resistance of chronic myeloid leukemia cells.
10/2014	Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms.
7/2014	Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth.

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Jinbao Liu Research Topics

Disease

65	Neoplasms (Cancer) 12/2022 - 09/2004
12	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 05/2009
9	Hepatocellular Carcinoma (Hepatoma) 05/2022 - 05/2009
8	Breast Neoplasms (Breast Cancer) 01/2021 - 01/2018
8	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2021 - 01/2014
7	Heart Failure 01/2022 - 02/2006
7	Multiple Myeloma 01/2021 - 06/2014
6	Carcinogenesis 11/2019 - 02/2016
5	Inflammation (Inflammations) 01/2022 - 05/2011
5	Lung Neoplasms (Lung Cancer) 08/2021 - 05/2009
5	Necrosis 01/2021 - 01/2011
4	Cardiotoxicity 01/2020 - 12/2005
4	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 08/2019 - 01/2017
4	Leukemia 01/2018 - 02/2011
3	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 12/2022 - 04/2015
3	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2020 - 07/2014
3	Cardiomyopathies (Cardiomyopathy) 01/2019 - 04/2006
3	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 10/2018 - 01/2011
3	Neoplasm Metastasis (Metastasis) 11/2017 - 01/2015
3	Cardiomegaly (Heart Hypertrophy) 01/2016 - 01/2013
2	Atherosclerosis 01/2022 - 01/2022
2	Body Weight (Weight, Body) 01/2022 - 01/2013
2	Rheumatoid Arthritis 08/2021 - 01/2016
2	Drug-Related Side Effects and Adverse Reactions 01/2021 - 12/2017
2	Hyperbilirubinemia 01/2021 - 01/2017
2	Kernicterus 01/2021 - 01/2020
2	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 01/2020
2	Adenocarcinoma 01/2020 - 11/2017
2	Adenocarcinoma of Lung 01/2020 - 01/2019
2	Colorectal Neoplasms (Colorectal Cancer) 04/2019 - 01/2017
2	Pancreatic Neoplasms (Pancreatic Cancer) 11/2017 - 07/2017
2	Heart Diseases (Heart Disease) 11/2015 - 02/2006
2	Hematologic Neoplasms (Hematological Malignancy) 06/2015 - 01/2015
2	Rheumatic Fever (Acute Articular Rheumatism) 10/2014 - 07/2014

Drug/Important Bio-Agent (IBA)

43	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2021 - 09/2004
23	Deubiquitinating EnzymesIBA 01/2022 - 06/2014
18	UbiquitinIBA 01/2022 - 04/2006
18	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2006
12	Proteasome InhibitorsIBA 01/2021 - 02/2011
11	Bortezomib (Velcade)FDA Link 01/2021 - 01/2012
10	Pharmaceutical PreparationsIBA 05/2022 - 07/2014
8	Ubiquitinated ProteinsIBA 12/2018 - 02/2006
7	BilirubinIBA 05/2022 - 01/2017
7	GoldIBA 08/2021 - 07/2014
7	Auranofin (Ridaura)FDA Link 08/2021 - 07/2014
7	CaspasesIBA 01/2018 - 01/2014
7	gambogic acidIBA 04/2015 - 02/2011
6	CopperIBA 01/2021 - 06/2014
6	Antineoplastic Agents (Antineoplastics)IBA 01/2021 - 02/2011
6	Androgen Receptors (Androgen Receptor)IBA 01/2020 - 01/2017
5	AndrogensIBA 01/2022 - 01/2017
5	MetalsIBA 08/2021 - 01/2015
5	pyrithioneIBA 01/2020 - 01/2015
5	Imatinib Mesylate (Gleevec)FDA Link 01/2017 - 01/2014
4	EnzymesIBA 01/2022 - 12/2017
4	Estrogen ReceptorsIBA 01/2021 - 01/2018
4	Messenger RNA (mRNA)IBA 01/2021 - 01/2012
4	Ubiquitin-Specific ProteasesIBA 11/2019 - 01/2016
4	Cisplatin (Platino)FDA LinkGeneric 01/2019 - 09/2016
4	Coordination ComplexesIBA 01/2019 - 06/2014
4	bcr-abl Fusion ProteinsIBA 01/2019 - 01/2014
4	Peptide Hydrolases (Proteases)FDA Link 01/2018 - 03/2010
3	carfilzomibIBA 01/2021 - 01/2015
3	Cullin Proteins (Cullins)IBA 01/2021 - 01/2011
3	Ligases (Synthetase)IBA 01/2020 - 01/2016
3	Biomarkers (Surrogate Marker)IBA 01/2020 - 06/2015
3	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 09/2016
3	Therapeutic UsesIBA 01/2018 - 09/2016
3	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2017 - 04/2014
3	Histones (Histone)IBA 07/2017 - 01/2012
3	platinum pyrithioneIBA 01/2017 - 09/2016
3	ATP dependent 26S protease (26S proteasome)IBA 09/2016 - 05/2009
3	Chymotrypsin FDA Link 06/2015 - 05/2009
3	Antirheumatic Agents (DMARD)IBA 11/2014 - 07/2014
2	tin protoporphyrin IXIBA 01/2022 - 01/2021
2	Heme Oxygenase-1IBA 01/2022 - 01/2021
2	LDL CholesterolIBA 01/2022 - 10/2021
2	Apolipoproteins E (ApoE)IBA 01/2022 - 01/2022
2	AlbuminsIBA 01/2021 - 01/2020
2	CatecholaminesIBA 01/2021 - 01/2019
2	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 01/2020 - 01/2019
2	NickelIBA 01/2020 - 11/2016
2	Cysteine (L-Cysteine)FDA Link 11/2019 - 04/2014
2	ErbB Receptors (EGF Receptor)IBA 08/2019 - 04/2019
2	enzalutamideIBA 05/2019 - 04/2019
2	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2019 - 12/2005
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2019 - 10/2018
2	Isoproterenol (Isoprenaline)FDA LinkGeneric 01/2019 - 01/2013
2	PolyphenolsIBA 01/2018 - 12/2017
2	HMGB1 Protein (HMG1)IBA 01/2018 - 07/2017
2	Acetylcysteine (Siran)FDA LinkGeneric 09/2017 - 04/2014
2	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneIBA 09/2017 - 01/2016
2	PlatinumIBA 01/2017 - 09/2016
2	Platinum Compounds (Compounds, Platinum)IBA 01/2017 - 09/2016
2	Protein AggregatesIBA 11/2015 - 04/2006
2	Interleukin-17 (Interleukin 17)IBA 10/2015 - 01/2015

Therapy/Procedure

36	Therapeutics 01/2022 - 12/2005
7	Drug Therapy (Chemotherapy) 12/2022 - 03/2010
3	Castration 01/2022 - 01/2020
3	Chinese Traditional Medicine (Traditional Chinese Medicine) 06/2020 - 05/2009